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UniProt functional annotation for O06553 | ||
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| UniProt code: O06553. |
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| Organism: | |
Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv). |
| Taxonomy: | |
Bacteria; Actinobacteria; Corynebacteriales; Mycobacteriaceae; Mycobacterium; Mycobacterium tuberculosis complex. |
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| Function: | |
F420H(2)-dependent reductase able to catalyze the reduction of biliverdin-IXalpha to bilirubin-IXalpha in vitro. However, kinetic parameters show that it is less efficient than the biliverdin reductase Rv2074 and suggest biliverdin-IXalpha is unlikely to be the native substrate of Rv1155, which probably catalyzes the reduction of an alternative molecule in vivo (PubMed:27364382). Binds coenzyme F420, but does not bind FMN or other flavins (PubMed:25644473). Cannot use pyridoxine 5'-phosphate, pyridoxamine 5'-phosphate, pyridoxal 5'- phosphate (PLP), the anti-tuberculosis drug PA-824 or aflatoxin analogs as substrates (PubMed:25644473). {ECO:0000269|PubMed:25644473, ECO:0000269|PubMed:27364382}. |
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| Biophysicochemical properties: | |
Kinetic parameters: KM=82.8 uM for biliverdin {ECO:0000269|PubMed:27364382}; Note=kcat is 0.024 sec(-1) for the reduction of biliverdin. {ECO:0000269|PubMed:27364382}; |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:15620716, ECO:0000269|PubMed:16239726, ECO:0000269|PubMed:25644473}. |
| Similarity: | |
Belongs to the F420H(2)-dependent biliverdin reductase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.