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UniProt functional annotation for P04058 | ||
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| UniProt code: P04058. |
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| Organism: | |
Tetronarce californica (Pacific electric ray) (Torpedo californica). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes; Elasmobranchii; Batoidea; Torpediniformes; Torpedinidae; Tetronarce. |
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| Function: | |
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. May be involved in cell-cell interactions. |
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| Catalytic activity: | |
Reaction=acetylcholine + H2O = acetate + choline + H(+); Xref=Rhea:RHEA:17561, ChEBI:CHEBI:15354, ChEBI:CHEBI:15355, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30089; EC=3.1.1.7; |
| Activity regulation: | |
Inhibited by substrate concentrations above 0.5 mM. {ECO:0000269|PubMed:16763558}. |
| Subunit: | |
Isoform H form is a homodimer; the asymmetric form is a disulfide-bonded oligomer composed of a collagenic subunit (Q) and a variable number of T catalytic subunits. {ECO:0000269|PubMed:10368299, ECO:0000269|PubMed:10606746, ECO:0000269|PubMed:11863435, ECO:0000269|PubMed:11888271, ECO:0000269|PubMed:15772291, ECO:0000269|PubMed:1678899, ECO:0000269|PubMed:19642642, ECO:0000269|PubMed:20025280, ECO:0000269|PubMed:8415649, ECO:0000269|PubMed:8747462, ECO:0000269|PubMed:8989325}. |
| Subcellular location: | |
[Isoform H]: Cell membrane; Lipid-anchor, GPI- anchor. Cell junction, synapse. |
| Subcellular location: | |
[Isoform T]: Cell membrane; Peripheral membrane protein. Cell junction, synapse. Note=Attached to the membrane through disulfide linkage with the collagenic subunit, itself bound to the membrane. |
| Tissue specificity: | |
Found in the synapses and to a lower extent in extrajunctional areas of muscle and nerve, and on erythrocyte membranes. |
| Ptm: | |
An interchain disulfide bond is present in what becomes position 593 of the T isoform. |
| Miscellaneous: | |
[Isoform H]: GPI-anchored form. |
| Similarity: | |
Belongs to the type-B carboxylesterase/lipase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.