PDBsum entry 1vty

DNA

PDB id: 1vty

Contents

DNA/RNA

Ligands

NH2 ×2

Metals

_MG

Waters ×83

References listed in PDB file

Key reference

• Title: Crystal structure of a z-Dna fragment containing thymine/2-Aminoadenine base pairs.
• Authors: M.Coll, A.H.Wang, G.A.Van der marel, J.H.Van boom, A.Rich.
• Ref.: J Biomol Struct Dyn, 1986, 4, 157-172. [DOI no: 10.1080/07391102.1986.10506337]
• PubMed id: 3271437

Abstract

The Z-DNA structure has been shown to form in two crystals made from self-complementary DNA hexamers d(CGTDCG) and d(CDCGTG) which contain thymine/2-aminoadenine (TD) base pairs. The latter structure has been solved and refined to 1.3 A resolution and it shows only small conformational changes due to the introduction of the TD base pairs in comparison with the structure of d(CG)3. Spectroscopic studies with these compounds demonstrate that DNA molecules containing 2-aminoadenine residues form Z-DNA slightly more easily than do those containing adenine nucleotides, but not as readily as the parent sequence containing only guanine-cytosine base pairs.