UniProt functional annotation for P43583



	UniProt functional annotation for P43583

UniProt code: P43583.

Organism: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).

Taxonomy: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.

Function: Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Involved in DNA damage response in somatic cells: binds to acetylated histones and promotes degradation of histones following DNA double-strand breaks. {ECO:0000269|PubMed:11842813, ECO:0000269|PubMed:12973301, ECO:0000269|PubMed:15778719, ECO:0000269|PubMed:18927584, ECO:0000269|PubMed:20227375, ECO:0000269|PubMed:22025621, ECO:0000269|PubMed:23706739}.

Subunit: According to PubMed:12973301, colocalizes with nascent proteasome. According to PubMed:15778719, associates with proteasome core particles and also forms a complex with regulatory particle-core particle (RP-CP). {ECO:0000269|PubMed:12973301, ECO:0000269|PubMed:15778719, ECO:0000269|PubMed:20227375}.

Subcellular location: Nucleus. Cytoplasm.

Domain: The bromodomain-like (BRDL) region specifically recognizes and binds acetylated histones. {ECO:0000269|PubMed:23706739}.

Domain: The YYX motif is required for the association with the proteasome. {ECO:0000269|PubMed:22025621}.

Miscellaneous: Present with 2600 molecules/cell in log phase SD medium. {ECO:0000269|PubMed:14562106}.

Similarity: Belongs to the BLM10 family. {ECO:0000305}.

Sequence caution: Sequence=BAA09231.1; Type=Frameshift; Note=Produces 2 separate ORFs.; Evidence={ECO:0000305}; Sequence=BAA09232.1; Type=Frameshift; Note=Produces 2 separate ORFs.; Evidence={ECO:0000305}; Sequence=Ref.6; Type=Frameshift; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast).
Taxonomy:		Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces.



Function:		Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin- independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Involved in DNA damage response in somatic cells: binds to acetylated histones and promotes degradation of histones following DNA double-strand breaks. {ECO:0000269\|PubMed:11842813, ECO:0000269\|PubMed:12973301, ECO:0000269\|PubMed:15778719, ECO:0000269\|PubMed:18927584, ECO:0000269\|PubMed:20227375, ECO:0000269\|PubMed:22025621, ECO:0000269\|PubMed:23706739}.


Subunit:		According to PubMed:12973301, colocalizes with nascent proteasome. According to PubMed:15778719, associates with proteasome core particles and also forms a complex with regulatory particle-core particle (RP-CP). {ECO:0000269\|PubMed:12973301, ECO:0000269\|PubMed:15778719, ECO:0000269\|PubMed:20227375}.
Subcellular location:		Nucleus. Cytoplasm.
Domain:		The bromodomain-like (BRDL) region specifically recognizes and binds acetylated histones. {ECO:0000269\|PubMed:23706739}.
Domain:		The YYX motif is required for the association with the proteasome. {ECO:0000269\|PubMed:22025621}.
Miscellaneous:		Present with 2600 molecules/cell in log phase SD medium. {ECO:0000269\|PubMed:14562106}.
Similarity:		Belongs to the BLM10 family. {ECO:0000305}.
Sequence caution:		Sequence=BAA09231.1; Type=Frameshift; Note=Produces 2 separate ORFs.; Evidence={ECO:0000305}; Sequence=BAA09232.1; Type=Frameshift; Note=Produces 2 separate ORFs.; Evidence={ECO:0000305}; Sequence=Ref.6; Type=Frameshift; Evidence={ECO:0000305};