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UniProt functional annotation for P04414 | ||
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| UniProt code: P04414. |
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| Organism: | |
Tetronarce californica (Pacific electric ray) (Torpedo californica). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Chondrichthyes; Elasmobranchii; Batoidea; Torpediniformes; Torpedinidae; Tetronarce. |
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| Function: | |
Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. |
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| Catalytic activity: | |
Reaction=ATP + creatine = ADP + H(+) + N-phosphocreatine; Xref=Rhea:RHEA:17157, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57947, ChEBI:CHEBI:58092, ChEBI:CHEBI:456216; EC=2.7.3.2; Evidence={ECO:0000255|PROSITE-ProRule:PRU10029}; |
| Subunit: | |
Dimer of identical or non-identical chains. With MM being the major form in skeletal muscle and myocardium, MB existing in myocardium, and BB existing in many tissues, especially brain. {ECO:0000269|PubMed:12437342}. |
| Subcellular location: | |
Cytoplasm. |
| Miscellaneous: | |
This electric ray muscle-specific creatine kinase (MM isozyme) is isolated from the electric organ, which derives embryologically from skeletal muscle. It may be involved in the electrical discharge process. |
| Similarity: | |
Belongs to the ATP:guanido phosphotransferase family. {ECO:0000255|PROSITE-ProRule:PRU00842, ECO:0000255|PROSITE- ProRule:PRU00843}. |
Annotations taken from UniProtKB at the EBI.