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UniProt functional annotation for P04084 | ||
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| UniProt code: P04084. |
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| Organism: | |
Vipera ammodytes meridionalis (Eastern sand viper). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Viperinae; Vipera. |
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| Function: | |
Heterodimer: postsynaptic neurotoxin. {ECO:0000269|PubMed:23554559}. |
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| Function: | |
Monomer: Acidic phospholipase A2 homolog that is non-toxic. {ECO:0000269|PubMed:23554559}. |
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| Subunit: | |
Heterodimer of A and B (AC P14420) chains; non-covalently linked. The A chain (acidic) is non-toxic, and increases the toxicity of the B chain (basic). The A chain may act as factor stabilizing the complex structure and hence retaining its toxicity by preventing non- specific binding. Upon binding to the target membranes the A chain may dissociate. {ECO:0000269|PubMed:11679719, ECO:0000269|PubMed:15003507, ECO:0000269|PubMed:23554559, ECO:0000269|PubMed:9276469}. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Toxic dose: | |
Heterodimer: LD(50) is 0.7-1.2 mg/kg by intraperitoneal injection into mice and 0.9-1.3 mg/kg by intravenous injection into mice. {ECO:0000269|PubMed:23554559}. |
| Toxic dose: | |
Heterodimer: LD(50) is 0.9-1.3 mg/kg by intravenous injection into mice. {ECO:0000269|PubMed:23554559}. |
| Toxic dose: | |
Monomer: LD(50) is >30 mg/kg by intraperitoneal injection into mice. {ECO:0000269|PubMed:23554559}. |
| Similarity: | |
Belongs to the phospholipase A2 family. Group II subfamily. D49 sub-subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.