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UniProt functional annotation for P01492 | ||
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| UniProt code: P01492. |
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| Organism: | |
Centruroides sculpturatus (Arizona bark scorpion). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Scorpiones; Buthida; Buthoidea; Buthidae; Centruroides. |
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| Function: | |
Beta toxins bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing (By similarity). Induces immediate paralysis in crickets after injection, with a total paralysis occurring within 15-30 minutes and lasting for 1-2 hours. Is also lethal to vertebrate (chicks) when injected in very high dosages (more than 100 mg/kg). {ECO:0000250, ECO:0000269|PubMed:4460885}. |
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| Subcellular location: | |
Secreted {ECO:0000269|PubMed:4460885}. |
| Tissue specificity: | |
Expressed by the venom gland. {ECO:0000269|PubMed:4460885}. |
| Domain: | |
Has the structural arrangement of an alpha-helix connected to antiparallel beta-sheets by disulfide bonds (CS-alpha/beta). {ECO:0000305}. |
| Toxic dose: | |
PD(50) is 11.0 mg/kg of insects (crickets). {ECO:0000269|PubMed:4460885}. |
| Similarity: | |
Belongs to the long (4 C-C) scorpion toxin superfamily. Sodium channel inhibitor family. Beta subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.