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UniProt functional annotation for P27248 | ||
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| UniProt code: P27248. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
The glycine cleavage system catalyzes the degradation of glycine. {ECO:0000255|HAMAP-Rule:MF_00259, ECO:0000269|PubMed:8375392}. |
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| Catalytic activity: | |
Reaction=(6S)-5,6,7,8-tetrahydrofolate + (R)-N(6)-(S(8)- aminomethyldihydrolipoyl)-L-lysyl-[protein] = (6R)-5,10-methylene- 5,6,7,8-tetrahydrofolate + (R)-N(6)-dihydrolipoyl-L-lysyl-[protein] + NH4(+); Xref=Rhea:RHEA:16945, Rhea:RHEA-COMP:10475, Rhea:RHEA- COMP:10492, ChEBI:CHEBI:15636, ChEBI:CHEBI:28938, ChEBI:CHEBI:57453, ChEBI:CHEBI:83100, ChEBI:CHEBI:83143; EC=2.1.2.10; Evidence={ECO:0000255|HAMAP-Rule:MF_00259}; |
| Subunit: | |
The glycine cleavage system is composed of four proteins: P, T, L and H. {ECO:0000255|HAMAP-Rule:MF_00259, ECO:0000269|PubMed:8375392}. |
| Similarity: | |
Belongs to the GcvT family. {ECO:0000255|HAMAP- Rule:MF_00259, ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.