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UniProt functional annotation for Q9X1H5 | ||
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| UniProt code: Q9X1H5. |
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| Organism: | |
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8). |
| Taxonomy: | |
Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga. |
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| Function: | |
Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. {ECO:0000269|PubMed:18591240}. |
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| Function: | |
Catalyzes the reversible cleavage of pseudouridine 5'- phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway. {ECO:0000255|HAMAP-Rule:MF_01876, ECO:0000269|PubMed:18591240}. |
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| Catalytic activity: | |
Reaction=D-ribose 5-phosphate + uracil = H2O + psi-UMP; Xref=Rhea:RHEA:18337, ChEBI:CHEBI:15377, ChEBI:CHEBI:17568, ChEBI:CHEBI:58380, ChEBI:CHEBI:78346; EC=4.2.1.70; Evidence={ECO:0000255|HAMAP-Rule:MF_01876, ECO:0000269|PubMed:18591240}; |
| Cofactor: | |
Name=Mn(2+); Xref=ChEBI:CHEBI:29035; Evidence={ECO:0000255|HAMAP-Rule:MF_01876, ECO:0000269|PubMed:15822122, ECO:0000303|PubMed:18591240}; Note=Binds 1 Mn(2+) ion per subunit. {ECO:0000255|HAMAP-Rule:MF_01876, ECO:0000269|PubMed:15822122, ECO:0000303|PubMed:18591240}; |
| Biophysicochemical properties: | |
Temperature dependence: No activity can be observed at or below 50 degrees Celsius. {ECO:0000269|PubMed:18591240}; |
| Subunit: | |
Homotrimer. {ECO:0000255|HAMAP-Rule:MF_01876, ECO:0000269|PubMed:15822122}. |
| Similarity: | |
Belongs to the pseudouridine-5'-phosphate glycosidase family. {ECO:0000255|HAMAP-Rule:MF_01876}. |
Annotations taken from UniProtKB at the EBI.