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UniProt functional annotation for Q923B0 | ||
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| UniProt code: Q923B0. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Contributes to degradation of proteins cross-linked by transglutaminases by degrading the cross-link between a lysine and a glutamic acid residue. Catalyzes the formation of 5-oxo-L-proline from L-gamma-glutamyl-L-epsilon-lysine. Inactive with L-gamma-glutamyl- alpha-amino acid substrates such as L-gamma-glutamyl-L-alpha-cysteine and L-gamma-glutamyl-L-alpha-alanine. {ECO:0000250|UniProtKB:Q9BVM4}. |
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| Catalytic activity: | |
Reaction=epsilon-(gamma-L-glutamyl)-L-lysine = 5-oxo-L-proline + L- lysine; Xref=Rhea:RHEA:16961, ChEBI:CHEBI:32551, ChEBI:CHEBI:58402, ChEBI:CHEBI:133752; EC=4.3.2.8; Evidence={ECO:0000250|UniProtKB:Q9BVM4}; |
| Subunit: | |
Monomer. {ECO:0000305|PubMed:16224779}. |
| Similarity: | |
Belongs to the gamma-glutamylcyclotransferase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.