UniProt functional annotation for Q9LUJ3



	UniProt functional annotation for Q9LUJ3

UniProt code: Q9LUJ3.

Organism: Arabidopsis thaliana (Mouse-ear cress).

Taxonomy: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.

Function: Regulator of RNA-directed DNA methylation (RdDM). Binds to single-stranded methyl DNA. Involved in the assembly of RNA polymerase V (Pol V) transcription initiation or elongation complexes at the chromatin, as a component of the DDR complex. {ECO:0000269|PubMed:20409711, ECO:0000269|PubMed:20410883, ECO:0000269|PubMed:22864289}.

Subunit: Homodimer. Interacts with AGO4, RPB205 and DRM2. Part of the chromatin-remodeling complex (DDR complex) that contains at least DRD1, DMS3 and RDM1. The DDR complex recruits/activates the RNA polymerases V and acts during siRNA-directed DNA methylation (RdDM). {ECO:0000269|PubMed:20409711, ECO:0000269|PubMed:20410883}.

Subcellular location: Nucleus, nucleoplasm {ECO:0000269|PubMed:20410883}. Note=Peri-nucleolar.

Disruption phenotype: Impaired accumulation of siRNAs, reduced DNA methylation, and loss of transcriptional gene silencing at RdDM target loci. Impaired RNA polymerase V-chromatin associations (Pol V). {ECO:0000269|PubMed:20409711, ECO:0000269|PubMed:20410883, ECO:0000269|PubMed:22864289}.

Annotations taken from UniProtKB at the EBI.


Organism:		Arabidopsis thaliana (Mouse-ear cress).
Taxonomy:		Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.



Function:		Regulator of RNA-directed DNA methylation (RdDM). Binds to single-stranded methyl DNA. Involved in the assembly of RNA polymerase V (Pol V) transcription initiation or elongation complexes at the chromatin, as a component of the DDR complex. {ECO:0000269\|PubMed:20409711, ECO:0000269\|PubMed:20410883, ECO:0000269\|PubMed:22864289}.


Subunit:		Homodimer. Interacts with AGO4, RPB205 and DRM2. Part of the chromatin-remodeling complex (DDR complex) that contains at least DRD1, DMS3 and RDM1. The DDR complex recruits/activates the RNA polymerases V and acts during siRNA-directed DNA methylation (RdDM). {ECO:0000269\|PubMed:20409711, ECO:0000269\|PubMed:20410883}.
Subcellular location:		Nucleus, nucleoplasm {ECO:0000269\|PubMed:20410883}. Note=Peri-nucleolar.
Disruption phenotype:		Impaired accumulation of siRNAs, reduced DNA methylation, and loss of transcriptional gene silencing at RdDM target loci. Impaired RNA polymerase V-chromatin associations (Pol V). {ECO:0000269\|PubMed:20409711, ECO:0000269\|PubMed:20410883, ECO:0000269\|PubMed:22864289}.