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UniProt functional annotation for Q9WYY1 | ||
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| UniProt code: Q9WYY1. |
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| Organism: | |
Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8). |
| Taxonomy: | |
Bacteria; Thermotogae; Thermotogales; Thermotogaceae; Thermotoga. |
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| Function: | |
Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP. Can remove uracil from double-stranded DNA containing either a U/G or U/A base pair as well as from single-stranded DNA. {ECO:0000269|PubMed:10339434, ECO:0000269|PubMed:11267830}. |
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| Catalytic activity: | |
Reaction=Hydrolyzes single-stranded DNA or mismatched double-stranded DNA and polynucleotides, releasing free uracil.; EC=3.2.2.27; Evidence={ECO:0000269|PubMed:10339434, ECO:0000269|PubMed:11267830}; |
| Biophysicochemical properties: | |
Temperature dependence: Remains fully active after heating 15 minutes at 85 degrees Celsius. Completely inactive after 15 minutes of pre-incubation at 95 degrees Celsius. {ECO:0000269|PubMed:11267830}; |
| Domain: | |
The seven N-terminal amino acids are important for maintaining proper protein folding and increase temperature stability of the protein. {ECO:0000269|PubMed:11267830}. |
| Similarity: | |
Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.