UniProt functional annotation for Q7SIB7



	UniProt functional annotation for Q7SIB7

UniProt code: Q7SIB7.

Organism: Sus scrofa (Pig).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.

Function: Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. {ECO:0000250|UniProtKB:P00558}.

Catalytic activity: Reaction=(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP; Xref=Rhea:RHEA:14801, ChEBI:CHEBI:30616, ChEBI:CHEBI:57604, ChEBI:CHEBI:58272, ChEBI:CHEBI:456216; EC=2.7.2.3; Evidence={ECO:0000250|UniProtKB:P00558};

Pathway: Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 2/5. {ECO:0000250|UniProtKB:P00558}.

Subunit: Monomer. {ECO:0000269|PubMed:11178909, ECO:0000269|PubMed:15035615}.

Subcellular location: Cytoplasm.

Similarity: Belongs to the phosphoglycerate kinase family. {ECO:0000305}.

Sequence caution: Sequence=Ref.3; Type=Miscellaneous discrepancy; Note=The sequence shown in PDB entry 1KF0 is a tentative sequence based on the electron density. It differs from that shown in 14 positions.; Evidence={ECO:0000305};

Annotations taken from UniProtKB at the EBI.


Organism:		Sus scrofa (Pig).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.



Function:		Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. {ECO:0000250\|UniProtKB:P00558}.


Catalytic activity:		Reaction=(2R)-3-phosphoglycerate + ATP = (2R)-3-phospho-glyceroyl phosphate + ADP; Xref=Rhea:RHEA:14801, ChEBI:CHEBI:30616, ChEBI:CHEBI:57604, ChEBI:CHEBI:58272, ChEBI:CHEBI:456216; EC=2.7.2.3; Evidence={ECO:0000250\|UniProtKB:P00558};
Pathway:		Carbohydrate degradation; glycolysis; pyruvate from D- glyceraldehyde 3-phosphate: step 2/5. {ECO:0000250\|UniProtKB:P00558}.
Subunit:		Monomer. {ECO:0000269\|PubMed:11178909, ECO:0000269\|PubMed:15035615}.
Subcellular location:		Cytoplasm.
Similarity:		Belongs to the phosphoglycerate kinase family. {ECO:0000305}.
Sequence caution:		Sequence=Ref.3; Type=Miscellaneous discrepancy; Note=The sequence shown in PDB entry 1KF0 is a tentative sequence based on the electron density. It differs from that shown in 14 positions.; Evidence={ECO:0000305};