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UniProt functional annotation for Q64512 | ||
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| UniProt code: Q64512. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Tyrosine phosphatase which regulates negatively FAS-induced apoptosis and NGFR-mediated pro-apoptotic signaling. May regulate phosphoinositide 3-kinase (PI3K) signaling through dephosphorylation of PIK3R2. {ECO:0000250|UniProtKB:Q12923}. |
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| Catalytic activity: | |
Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] + phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA- COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858, ChEBI:CHEBI:82620; EC=3.1.3.48; Evidence={ECO:0000250|UniProtKB:Q12923}; |
| Subunit: | |
Interacts (via the first PDZ domain) with PLEKHA1 and PLEKHA2. Interacts (via the second PDZ domain) with TNFRSF6 (Fas receptor) (via C-terminus) (By similarity). Interacts (via the second PDZ domain) with TRIP6 (via the third LIM domain and C-terminus) (PubMed:10826496). Interacts (via the third PDZ domain) with NGFR (via C-terminal SVP motif) and PKN2 (via C-terminus) (By similarity). Interacts (via the second or fourth PDZ domains) with PDLIM4 (via C-terminus only or via combined C-terminus and LIM domain, but not LIM domain only) (PubMed:9487134, PubMed:15663004). Found in a complex with PDLIM4 and TRIP6 (PubMed:10826496). Interacts with PDLIM4; this interaction results in dephosphorylation of SRC 'Tyr-419' by this protein leading to its inactivation (By similarity). Interacts with BRD7 (PubMed:10526152). Interacts with RAPGEF6. Interacts with ARHGAP29. Interacts with PIK3R2; dephosphorylates PIK3R2. Interacts with FBXL2 (By similarity). Interacts (via the FERM domain) with ENTR1 (PubMed:23108400). Found in a complex with ENTR1, PTPN13 and GIT1 (PubMed:23108400). {ECO:0000250|UniProtKB:Q12923, ECO:0000269|PubMed:10526152, ECO:0000269|PubMed:10826496, ECO:0000269|PubMed:15663004, ECO:0000269|PubMed:23108400, ECO:0000269|PubMed:9487134}. |
| Subcellular location: | |
Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q12923}. Nucleus {ECO:0000250|UniProtKB:Q12923}. Cell projection, lamellipodium {ECO:0000250|UniProtKB:Q12923}. Note=Colocalizes with PKN2 in lamellipodia-like structure, regions of large actin turnover. {ECO:0000250|UniProtKB:Q12923}. |
| Tissue specificity: | |
Expressed predominantly in kidney and, to a lesser extent, in lung, heart, brain and testis. |
| Similarity: | |
Belongs to the protein-tyrosine phosphatase family. Non- receptor class subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.