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PDBsum entry 1vj2
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Metal binding protein
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PDB id
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1vj2
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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Crystal structure of a novel manganese-Containing cupin (tm1459) from thermotoga maritima at 1.65 a resolution.
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Authors
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L.Jaroszewski,
R.Schwarzenbacher,
F.Von delft,
D.Mcmullan,
L.S.Brinen,
J.M.Canaves,
X.Dai,
A.M.Deacon,
M.Didonato,
M.A.Elsliger,
S.Eshagi,
R.Floyd,
A.Godzik,
C.Grittini,
S.K.Grzechnik,
E.Hampton,
I.Levin,
C.Karlak,
H.E.Klock,
E.Koesema,
J.S.Kovarik,
A.Kreusch,
P.Kuhn,
S.A.Lesley,
T.M.Mcphillips,
M.D.Miller,
A.Morse,
K.Moy,
J.Ouyang,
R.Page,
K.Quijano,
R.Reyes,
F.Rezezadeh,
A.Robb,
E.Sims,
G.Spraggon,
R.C.Stevens,
H.Van den bedem,
J.Velasquez,
J.Vincent,
X.Wang,
B.West,
G.Wolf,
Q.Xu,
K.O.Hodgson,
J.Wooley,
I.A.Wilson.
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Ref.
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Proteins, 2004,
56,
611-614.
[DOI no: ]
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PubMed id
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Abstract
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No abstract given.
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Figure 1.
Figure 1. Crystal structure of TM1459 shown as (a) ribbon
diagram of Thermotoga maritima TM1459 color coded from
N-terminus (blue) to C-terminus (red) showing the domain
organization and the location of the manganese ion (purple
sphere). The 3[10]-helices (H1, H2),  -strands
( [1]-
[11]
and -sheets
A and B are indicated; and (b) ribbon diagram of TM1459 dimer.
-strands
1
and 9
of the crossover domain-swap interaction are indicated and are
labeled 1
 and
9
in
the opposing subunit.
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Figure 2.
Figure 2. (a) Diagram showing the secondary structure elements
in TM1459 superimposed on its primary sequence. -Hairpins
are depicted as red loops. Residues coordinating the metal ion
are marked with blue dots. (b) The active site of TM1459 showing
the proposed manganese ion (Mn), its coordinating residues
(His52, His54, His58, His92, and two waters) and Cys106,
adjacent to the unidentified density modeled as UNL, is depicted
in ball and stick. The atoms are indicated as follows: carbon
(grey), oxygen (red), nitrogen (blue), sulfur (orange) and
manganese (purple). Metal-ligand bonds are represented as dashed
yellow lines.
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The above figures are
reprinted
by permission from John Wiley & Sons, Inc.:
Proteins
(2004,
56,
611-614)
copyright 2004.
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