|
|
||
|
|
|
|
|
UniProt functional annotation for O29866 | ||
|
|
|
|
|
|
||
| UniProt code: O29866. |
|
||
| Organism: | |
Archaeoglobus fulgidus (strain ATCC 49558 / VC-16 / DSM 4304 / JCM 9628 / NBRC 100126). |
| Taxonomy: | |
Archaea; Euryarchaeota; Archaeoglobi; Archaeoglobales; Archaeoglobaceae; Archaeoglobus. |
|
||
|
||
| Function: | |
S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01084}. |
|
||
| Catalytic activity: | |
Reaction=2-[(3S)-amino-3-carboxypropyl]-L-histidyl-[translation elongation factor 2] + 3 S-adenosyl-L-methionine = diphthine- [translation elongation factor 2] + 3 H(+) + 3 S-adenosyl-L- homocysteine; Xref=Rhea:RHEA:36415, Rhea:RHEA-COMP:9749, Rhea:RHEA- COMP:10172, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789, ChEBI:CHEBI:73995, ChEBI:CHEBI:82696; EC=2.1.1.98; Evidence={ECO:0000255|HAMAP-Rule:MF_01084}; |
| Pathway: | |
Protein modification; peptidyl-diphthamide biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01084}. |
| Subunit: | |
Homodimer. {ECO:0000255|HAMAP-Rule:MF_01084}. |
| Similarity: | |
Belongs to the diphthine synthase family. {ECO:0000255|HAMAP-Rule:MF_01084}. |
Annotations taken from UniProtKB at the EBI.