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UniProt functional annotation for P76270 | ||
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| UniProt code: P76270. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Catalyzes the reversible oxidation-reduction of the R- enantiomer of free methionine sulfoxide to methionine. Specific for free L-methionine-(R)-S-oxide. {ECO:0000269|PubMed:17535911}. |
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| Catalytic activity: | |
Reaction=[thioredoxin]-disulfide + H2O + L-methionine = [thioredoxin]- dithiol + L-methionine (R)-S-oxide; Xref=Rhea:RHEA:21260, Rhea:RHEA- COMP:10698, Rhea:RHEA-COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058, ChEBI:CHEBI:57844, ChEBI:CHEBI:58773; EC=1.8.4.14; Evidence={ECO:0000269|PubMed:17535911}; |
| Biophysicochemical properties: | |
Kinetic parameters: KM=3.9 mM for L-methionine-(R)-S-oxide {ECO:0000269|PubMed:17535911}; KM=9.8 uM for thioredoxin {ECO:0000269|PubMed:17535911}; |
| Similarity: | |
Belongs to the free Met sulfoxide reductase family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=BAA15640.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.