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UniProt functional annotation for P39739 | ||
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| UniProt code: P39739. |
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| Organism: | |
Bacillus subtilis (strain 168). |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus. |
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| Function: | |
Essential for filament assembly (PubMed:23144244). May act as a facilitator of flagellin (hag) secretion. Antagonizes translational repressor CsrA indirectly (PubMed:23144244). {ECO:0000269|PubMed:23144244}. |
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| Subunit: | |
Homodimer (PubMed:23144244, PubMed:16021622). Interacts directly with flagellin (hag), forms a 3-way complex of Hag, FliS and FliW in which Flis and FliW do not directly interact (PubMed:23144244). {ECO:0000269|PubMed:23144244, ECO:0000305|PubMed:16021622}. |
| Subcellular location: | |
Cytoplasm, cytosol {ECO:0000305}. |
| Disruption phenotype: | |
Severe defect in motility on agar plates, forms multiple short filament stubs on the cell surface, decreased expression of flagellin (hag), 30-fold decrease in Hag secretion. All phenotypes are partially suppressed by deletion of csrA, which increases translation of Hag (PubMed:23144244). {ECO:0000269|PubMed:23144244}. |
| Similarity: | |
Belongs to the FliS family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.