UniProt functional annotation for P33173



	UniProt functional annotation for P33173

UniProt code: P33173.

Organism: Mus musculus (Mouse).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.

Function: Motor for anterograde axonal transport of synaptic vesicle precursors (Probable). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites (By similarity). {ECO:0000250|UniProtKB:F1M4A4, ECO:0000305}.

Subunit: Monomer. Interacts with PPFIA1 and PPFIA4 (By similarity). Interacts with CALM1; the interaction is increased in presence of calcium and increases neuronal dense core vesicles motility. Interacts with PPFIA2 and TANC2; both interactions allow the recruitment of neuronal dense core vesicles to dendritic spines and decrease in presence of calcium (By similarity). Interacts with SYT4 (unphosphorylated) and SYT11; both interactions increase in presence of calcium (By similarity) (PubMed:30808661). Interacts with MADD (PubMed:18849981). {ECO:0000250|UniProtKB:F1M4A4, ECO:0000269|PubMed:18849981, ECO:0000269|PubMed:30808661}.

Subcellular location: Cytoplasm, cytoskeleton {ECO:0000250|UniProtKB:Q12756}. Cell projection, axon {ECO:0000269|PubMed:7539720}. Cytoplasm, perinuclear region {ECO:0000269|PubMed:7539720}. Cell junction, synapse. Cell projection, neuron projection {ECO:0000250|UniProtKB:Q12756}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane {ECO:0000250|UniProtKB:F1M4A4}; Peripheral membrane protein {ECO:0000250|UniProtKB:F1M4A4}; Cytoplasmic side {ECO:0000250|UniProtKB:F1M4A4}. Note=Within neuronal cells concentrated in the axon, with smaller amounts in the perinuclear and synaptic regions (PubMed:7539720). Expressed in distal regions of neurites. {ECO:0000250|UniProtKB:Q12756, ECO:0000269|PubMed:7539720}.

Tissue specificity: Expressed almost exclusively in neuronal tissues such as brain and spinal cord (at protein level) (PubMed:7539720, PubMed:18849981). Expressed at lower levels in the adrenal gland (at protein level) (PubMed:7539720). {ECO:0000269|PubMed:18849981, ECO:0000269|PubMed:7539720}.

Similarity: Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily. {ECO:0000255|PROSITE- ProRule:PRU00283}.

Annotations taken from UniProtKB at the EBI.


Organism:		Mus musculus (Mouse).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus.



Function:		Motor for anterograde axonal transport of synaptic vesicle precursors (Probable). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites (By similarity). {ECO:0000250\|UniProtKB:F1M4A4, ECO:0000305}.


Subunit:		Monomer. Interacts with PPFIA1 and PPFIA4 (By similarity). Interacts with CALM1; the interaction is increased in presence of calcium and increases neuronal dense core vesicles motility. Interacts with PPFIA2 and TANC2; both interactions allow the recruitment of neuronal dense core vesicles to dendritic spines and decrease in presence of calcium (By similarity). Interacts with SYT4 (unphosphorylated) and SYT11; both interactions increase in presence of calcium (By similarity) (PubMed:30808661). Interacts with MADD (PubMed:18849981). {ECO:0000250\|UniProtKB:F1M4A4, ECO:0000269\|PubMed:18849981, ECO:0000269\|PubMed:30808661}.
Subcellular location:		Cytoplasm, cytoskeleton {ECO:0000250\|UniProtKB:Q12756}. Cell projection, axon {ECO:0000269\|PubMed:7539720}. Cytoplasm, perinuclear region {ECO:0000269\|PubMed:7539720}. Cell junction, synapse. Cell projection, neuron projection {ECO:0000250\|UniProtKB:Q12756}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane {ECO:0000250\|UniProtKB:F1M4A4}; Peripheral membrane protein {ECO:0000250\|UniProtKB:F1M4A4}; Cytoplasmic side {ECO:0000250\|UniProtKB:F1M4A4}. Note=Within neuronal cells concentrated in the axon, with smaller amounts in the perinuclear and synaptic regions (PubMed:7539720). Expressed in distal regions of neurites. {ECO:0000250\|UniProtKB:Q12756, ECO:0000269\|PubMed:7539720}.
Tissue specificity:		Expressed almost exclusively in neuronal tissues such as brain and spinal cord (at protein level) (PubMed:7539720, PubMed:18849981). Expressed at lower levels in the adrenal gland (at protein level) (PubMed:7539720). {ECO:0000269\|PubMed:18849981, ECO:0000269\|PubMed:7539720}.
Similarity:		Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. Unc-104 subfamily. {ECO:0000255\|PROSITE- ProRule:PRU00283}.