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UniProt functional annotation for P26697 | ||
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| UniProt code: P26697. |
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| Organism: | |
Gallus gallus (Chicken). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus. |
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| Function: | |
Catalyzes the conjugation of GSH to a wide variety of electrophilic alkylating agents. Also involved in the metabolism of lipid hydroperoxides, prostaglandins and leukotriene A4 and in binding of non-substrate hydrophobic ligands such as bile acids, a number of drugs and thyroid hormones. This GST does not exhibit peroxidase activity. |
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| Catalytic activity: | |
Reaction=glutathione + RX = a halide anion + an S-substituted glutathione + H(+); Xref=Rhea:RHEA:16437, ChEBI:CHEBI:15378, ChEBI:CHEBI:16042, ChEBI:CHEBI:17792, ChEBI:CHEBI:57925, ChEBI:CHEBI:90779; EC=2.5.1.18; Evidence={ECO:0000250|UniProtKB:Q16772}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16438; Evidence={ECO:0000250|UniProtKB:Q16772}; |
| Subunit: | |
Homodimer or heterodimer (with a subunit from group CL-4). |
| Subcellular location: | |
Cytoplasm. |
| Miscellaneous: | |
The variations were found from AA sequencing and imply there are multiple forms of CL-3. |
| Similarity: | |
Belongs to the GST superfamily. Alpha family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.