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UniProt functional annotation for P35446 | ||
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| UniProt code: P35446. |
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| Organism: | |
Rattus norvegicus (Rat). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus. |
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| Function: | |
Cell adhesion protein that promotes the attachment of spinal cord and sensory neuron cells and the outgrowth of neurites in vitro. May contribute to the growth and guidance of axons in both the spinal cord and the PNS. |
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| Subunit: | |
Binds to the central extracellular domain of APP and inhibits beta-secretase cleavage of APP. |
| Subcellular location: | |
Secreted, extracellular space, extracellular matrix. |
| Tissue specificity: | |
Expressed at high levels in the floor plate. |
Annotations taken from UniProtKB at the EBI.