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UniProt functional annotation for P15093 | ||
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| UniProt code: P15093. |
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| Organism: | |
Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2) (Halobacterium volcanii). |
| Taxonomy: | |
Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Haloferacales; Haloferacaceae; Haloferax. |
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| Function: | |
Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. {ECO:0000269|PubMed:2509470}. |
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| Catalytic activity: | |
Reaction=(6S)-5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + H(+) + NADPH; Xref=Rhea:RHEA:15009, ChEBI:CHEBI:15378, ChEBI:CHEBI:57451, ChEBI:CHEBI:57453, ChEBI:CHEBI:57783, ChEBI:CHEBI:58349; EC=1.5.1.3; Evidence={ECO:0000255|PROSITE- ProRule:PRU00660, ECO:0000269|PubMed:2509470}; |
| Activity regulation: | |
Activity unstable at KCl and NaCl concentrations lower than 2 M and activity increases with increasing concentrations of KCl or NaCl. {ECO:0000269|PubMed:2509470}. |
| Pathway: | |
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8- tetrahydrofolate from 7,8-dihydrofolate: step 1/1. |
| Similarity: | |
Belongs to the dihydrofolate reductase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.