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UniProt functional annotation for Q8R1G6 | ||
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| UniProt code: Q8R1G6. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity). {ECO:0000250}. |
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| Subunit: | |
Interacts with alpha-actinins ACTN1 and ACTN4, FLNA and MYH9. {ECO:0000250}. |
| Subcellular location: | |
Cytoplasm. Cytoplasm, cytoskeleton. Note=Localizes at the cytoskeleton. Colocalizes with beta-1 integrin (ITGB1) and alpha-actinin but not with paxillin (PXN) (By similarity). {ECO:0000250}. |
| Tissue specificity: | |
Highly expressed in lung. Expressed at intermediate level in kidney, testis and spleen. Weakly expressed in heart and brain. {ECO:0000269|PubMed:15659642}. |
| Induction: | |
Regulated by IGF-1. {ECO:0000269|PubMed:15659642}. |
Annotations taken from UniProtKB at the EBI.