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UniProt functional annotation for P80958 | ||
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| UniProt code: P80958. |
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| Organism: | |
Naja atra (Chinese cobra). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Naja. |
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| Function: | |
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Has a lower toxicity than cobrotoxin. {ECO:0000269|PubMed:9498573}. |
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| Subcellular location: | |
Secreted {ECO:0000269|PubMed:9498573}. |
| Tissue specificity: | |
Expressed by the venom gland. {ECO:0000305}. |
| Mass spectrometry: | |
Mass=6950; Method=MALDI; Evidence={ECO:0000269|PubMed:12777767}; |
| Toxic dose: | |
LD(50) is 0.18 mg/kg by intravenous injection into mice. {ECO:0000269|PubMed:12777767}. |
| Similarity: | |
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.