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UniProt functional annotation for P00921 | ||
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| UniProt code: P00921. |
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| Organism: | |
Bos taurus (Bovine). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos. |
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| Function: | |
Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. {ECO:0000250}. |
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| Catalytic activity: | |
Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:17544; EC=4.2.1.1; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000269|PubMed:15039588}; |
| Activity regulation: | |
Inhibited by acetazolamide. {ECO:0000250}. |
| Subunit: | |
Interacts with SLC4A4. Interaction with SLC4A7 regulates SLC4A7 transporter activity (By similarity). {ECO:0000250}. |
| Subcellular location: | |
Cytoplasm. |
| Miscellaneous: | |
One minor and two major forms were isolated chromatographically. |
| Similarity: | |
Belongs to the alpha-carbonic anhydrase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.