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UniProt functional annotation for P83257 | ||
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| UniProt code: P83257. |
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| Organism: | |
Pireneitega luctuosa (Tangled nest spider) (Paracoelotes luctuosus). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Araneomorphae; Entelegynae; Amaurobiidae; Pireneitega. |
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| Function: | |
Insecticidal toxin. Lethal to lepidopteran larvae. No adverse affects when intracerebroventricularly injected in mice at a dose of 0.2 ug but causes reversible paralysis of legs when injected intracerebroventricularly in mice at a dose of 2.0 ug. Binds to site 4 of insect voltage-gated sodium channel (Nav) and inhibits channel inactivation. {ECO:0000269|PubMed:10971590, ECO:0000269|PubMed:15683238}. |
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| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. {ECO:0000269|PubMed:10971590}. |
| Domain: | |
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. |
| Mass spectrometry: | |
Mass=4114.6; Method=MALDI; Evidence={ECO:0000269|PubMed:10971590}; |
| Toxic dose: | |
LD(50) is 24.2 ng/mg body weight of lepidoptera larvae. {ECO:0000269|PubMed:15683238}. |
| Similarity: | |
Belongs to the neurotoxin 07 (Beta/delta-agtx) family. 02 (aga-3) subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.