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UniProt functional annotation for P61230 | ||
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| UniProt code: P61230. |
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| Organism: | |
Paraphysa scrofa (Chilean copper tarantula) (Phrixotrichus auratus). |
| Taxonomy: | |
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida; Araneae; Mygalomorphae; Theraphosidae; Paraphysa. |
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| Function: | |
Potent and specific blocker of Kv4.2/KCND2 (IC(50)=5 nM) and Kv4.3/KCND3 (IC(50)=28 nM) potassium channels (PubMed:10051143). Acts by altering the gating properties of these channels (PubMed:10051143). Also shows moderate inhibition on human voltage-gated sodium channel Nav1.7/SCN9A activation (IC(50)=423 nM) (PubMed:25026046). {ECO:0000269|PubMed:10051143, ECO:0000269|PubMed:25026046}. |
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| Subcellular location: | |
Secreted {ECO:0000269|PubMed:10051143}. |
| Tissue specificity: | |
Expressed by the venom gland. {ECO:0000305|PubMed:10051143}. |
| Domain: | |
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. {ECO:0000269|PubMed:15096626}. |
| Mass spectrometry: | |
Mass=3547.60; Method=Electrospray; Evidence={ECO:0000269|PubMed:10051143}; |
| Miscellaneous: | |
This toxin does not inhibit Kv1/KCNA, Kv2/KCNB, Kv3/KCNC, and Kv11/KCNH channels (PubMed:10051143). It weakly blocks the neuronal TTX-sensitive sodium currents of neuroblastoma cells (13% inhibition at 100 nM) (PubMed:10051143). Does not inhibit sodium channel Nav1.2/SCN2A (PubMed:25026046). {ECO:0000269|PubMed:10051143, ECO:0000269|PubMed:25026046}. |
| Similarity: | |
Belongs to the neurotoxin 30 (phrixotoxin) family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.