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UniProt functional annotation for P60770 | ||
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| UniProt code: P60770. |
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| Organism: | |
Naja atra (Chinese cobra). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Naja. |
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| Function: | |
Binds to muscle nicotinic acetylcholine receptor (nAChR) and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. Has a higher toxicity than cobrotoxin-b (PubMed:9498573). In vivo, when tested on rat arthritis models, shows anti-inflammation and immunosuppression effects (PubMed:27840083). {ECO:0000269|PubMed:27840083, ECO:0000269|PubMed:9498573}. |
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| Subcellular location: | |
Secreted {ECO:0000269|PubMed:5820687}. |
| Tissue specificity: | |
Expressed by the venom gland. {ECO:0000305}. |
| Mass spectrometry: | |
Mass=6952; Method=MALDI; Evidence={ECO:0000269|PubMed:11976497}; |
| Toxic dose: | |
LD(50) is 0.09 mg/kg by subcutaneous injection. |
| Pharmaceutical: | |
Analgesic available under the trade name Cobratide (approved by the National Medical Products Administration of China). Has been safely used since 1978. {ECO:0000305|PubMed:27840083, ECO:0000305|PubMed:32843715}. |
| Similarity: | |
Belongs to the snake three-finger toxin family. Short-chain subfamily. Type I alpha-neurotoxin sub-subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.