|
|
||
|
|
|
|
|
UniProt functional annotation for P25976 | ||
|
|
|
|
|
|
||
| UniProt code: P25976. |
|
||
| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
|
||
|
||
| Function: | |
Recognizes the ribosomal RNA gene promoter and activates transcription mediated by RNA polymerase I through cooperative interactions with the transcription factor SL1/TIF-IB complex. It binds specifically to the upstream control element. {ECO:0000269|PubMed:20168301}. |
|
||
| Subunit: | |
Homodimer (By similarity). Interacts with TBP (By similarity). Interacts with TAF1A (By similarity). Interacts with RASL11A (PubMed:20168301). Binds to IRS1 and PIK3CA (PubMed:15197263). Interacts with DHX33 (PubMed:21930779). Interacts with PHF6 (By similarity). Interacts with CEBPA (isoform 1 and isoform 4) (By similarity). Interacts with DDX11 (By similarity). Interacts with NOP53 (By similarity). {ECO:0000250|UniProtKB:P17480, ECO:0000250|UniProtKB:P25977, ECO:0000269|PubMed:15197263, ECO:0000269|PubMed:20168301, ECO:0000269|PubMed:21930779}. |
| Subcellular location: | |
Nucleus, nucleolus {ECO:0000269|PubMed:20168301}. |
| Ptm: | |
Phosphorylated and activated by PIK3CA. {ECO:0000269|PubMed:17182730}. |
Annotations taken from UniProtKB at the EBI.