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UniProt functional annotation for Q9C0E4 | ||
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| UniProt code: Q9C0E4. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
May play a role as a localized scaffold for the assembly of a multiprotein signaling complex and as mediator of the trafficking of its binding partners at specific subcellular location in neurons. {ECO:0000250}. |
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| Subunit: | |
Interacts with EFNB1, EFNB3, GRIA2, GRIA3, CSPG4 and GRIPAP1. Can form homomultimers and heteromultimers with GRIP1 (By similarity). Interacts with the C-terminal tail of PRLHR. {ECO:0000250, ECO:0000269|PubMed:11641419}. |
| Subcellular location: | |
Cytoplasm {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. |
| Domain: | |
PDZ 5 mediates the C-terminal binding of GRIA2 and GRIA3. PDZ 6 mediates interaction with the PDZ recognition motif of EFNB1. PDZ 7 mediates interaction with CSPG4 (By similarity). {ECO:0000250}. |
| Miscellaneous: | |
[Isoform 2]: Due to intron retention. {ECO:0000305}. |
| Miscellaneous: | |
[Isoform 3]: Incomplete sequence. Due to intron retention. {ECO:0000305}. |
| Similarity: | |
Belongs to the GRIP2 family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=BAB21810.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.