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UniProt functional annotation for P31949 | ||
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| UniProt code: P31949. |
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| Organism: | |
Homo sapiens (Human). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. |
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| Function: | |
Facilitates the differentiation and the cornification of keratinocytes. {ECO:0000269|PubMed:18618420}. |
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| Subunit: | |
Homodimer; disulfide-linked. {ECO:0000269|PubMed:18618420}. |
| Subcellular location: | |
Cytoplasm {ECO:0000269|PubMed:18618420}. Nucleus {ECO:0000269|PubMed:18618420}. |
| Ptm: | |
Phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation. {ECO:0000269|PubMed:18618420}. |
| Miscellaneous: | |
Binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins. {ECO:0000250}. |
| Similarity: | |
Belongs to the S-100 family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.