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UniProt functional annotation for F9VN03 | ||
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| UniProt code: F9VN03. |
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| Organism: | |
Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii). |
| Taxonomy: | |
Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae; Sulfurisphaera. |
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| Function: | |
Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. {ECO:0000256|HAMAP-Rule:MF_01963}. |
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| Catalytic activity: | |
Reaction=phosphate + S-methyl-5'-thioadenosine = adenine + S-methyl-5- thio-alpha-D-ribose 1-phosphate; Xref=Rhea:RHEA:11852, ChEBI:CHEBI:16708, ChEBI:CHEBI:17509, ChEBI:CHEBI:43474, ChEBI:CHEBI:58533; EC=2.4.2.28; Evidence={ECO:0000256|HAMAP- Rule:MF_01963}; |
| Pathway: | |
Amino-acid biosynthesis; L-methionine biosynthesis via salvage pathway; S-methyl-5-thio-alpha-D-ribose 1-phosphate from S-methyl-5'- thioadenosine (phosphorylase route): step 1/1. {ECO:0000256|HAMAP- Rule:MF_01963}. |
| Subunit: | |
Homohexamer. Dimer of a homotrimer. {ECO:0000256|HAMAP- Rule:MF_01963}. |
| Similarity: | |
Belongs to the PNP/MTAP phosphorylase family. {ECO:0000256|ARBA:ARBA00006751}. |
| Similarity: | |
Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. {ECO:0000256|HAMAP-Rule:MF_01963}. |
Annotations taken from UniProtKB at the EBI.