UniProt functional annotation for P20248



	UniProt functional annotation for P20248

UniProt code: P20248.

Organism: Homo sapiens (Human).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.

Function: Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin- dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. {ECO:0000269|PubMed:1312467}.

Subunit: Interacts with the CDK1 and CDK2 protein kinases to form serine/threonine kinase holoenzyme complexes (PubMed:1312467, PubMed:7630397, PubMed:8684460, PubMed:8756328). Interacts with CDK1 (hyperphosphorylated form in G1 and underphosphorylated forms in S and G2) (PubMed:1312467). Interacts with CDK2; the interaction increases from G1 to G2 (PubMed:1312467). Interacts (associated with CDK2 but not with CDK1) with SCAPER; regulates the activity of CCNA2/CDK2 by transiently maintaining CCNA2 in the cytoplasm (PubMed:17698606). Forms a ternary complex with CDK2 and CDKN1B; CDKN1B inhibits the kinase activity of CDK2 through conformational rearrangements (PubMed:8684460). Interacts with INCA1 (PubMed:21540187). {ECO:0000269|PubMed:1312467, ECO:0000269|PubMed:17698606, ECO:0000269|PubMed:21540187, ECO:0000269|PubMed:7630397, ECO:0000269|PubMed:8684460, ECO:0000269|PubMed:8756328}.

Subunit: (Microbial infection) Interacts with human cytomegalovirus protein UL32. {ECO:0000269|PubMed:24101496}.

Subcellular location: Nucleus {ECO:0000269|PubMed:1312467, ECO:0000269|PubMed:17698606}. Cytoplasm {ECO:0000269|PubMed:1312467, ECO:0000269|PubMed:17698606}. Note=Exclusively nuclear during interphase (PubMed:1312467). Detected in the nucleus and the cytoplasm at prophase (PubMed:1312467). Cytoplasmic when associated with SCAPER (PubMed:17698606). {ECO:0000269|PubMed:1312467, ECO:0000269|PubMed:17698606}.

Developmental stage: Accumulates steadily during G2 and is abruptly destroyed at mitosis. Not detected during the G1 phase of the cell cycle. It accumulates during the DNA synthesis/S phase and disappears as cells progress into mitosis, between prophase and metaphase (at protein level). {ECO:0000269|PubMed:1312467}.

Ptm: Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase- promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase. {ECO:0000269|PubMed:21596315}.

Similarity: Belongs to the cyclin family. Cyclin AB subfamily. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Homo sapiens (Human).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo.



Function:		Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine protein kinase holoenzyme complexes with the cyclin- dependent protein kinases CDK1 or CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. {ECO:0000269\|PubMed:1312467}.


Subunit:		Interacts with the CDK1 and CDK2 protein kinases to form serine/threonine kinase holoenzyme complexes (PubMed:1312467, PubMed:7630397, PubMed:8684460, PubMed:8756328). Interacts with CDK1 (hyperphosphorylated form in G1 and underphosphorylated forms in S and G2) (PubMed:1312467). Interacts with CDK2; the interaction increases from G1 to G2 (PubMed:1312467). Interacts (associated with CDK2 but not with CDK1) with SCAPER; regulates the activity of CCNA2/CDK2 by transiently maintaining CCNA2 in the cytoplasm (PubMed:17698606). Forms a ternary complex with CDK2 and CDKN1B; CDKN1B inhibits the kinase activity of CDK2 through conformational rearrangements (PubMed:8684460). Interacts with INCA1 (PubMed:21540187). {ECO:0000269\|PubMed:1312467, ECO:0000269\|PubMed:17698606, ECO:0000269\|PubMed:21540187, ECO:0000269\|PubMed:7630397, ECO:0000269\|PubMed:8684460, ECO:0000269\|PubMed:8756328}.
Subunit:		(Microbial infection) Interacts with human cytomegalovirus protein UL32. {ECO:0000269\|PubMed:24101496}.
Subcellular location:		Nucleus {ECO:0000269\|PubMed:1312467, ECO:0000269\|PubMed:17698606}. Cytoplasm {ECO:0000269\|PubMed:1312467, ECO:0000269\|PubMed:17698606}. Note=Exclusively nuclear during interphase (PubMed:1312467). Detected in the nucleus and the cytoplasm at prophase (PubMed:1312467). Cytoplasmic when associated with SCAPER (PubMed:17698606). {ECO:0000269\|PubMed:1312467, ECO:0000269\|PubMed:17698606}.
Developmental stage:		Accumulates steadily during G2 and is abruptly destroyed at mitosis. Not detected during the G1 phase of the cell cycle. It accumulates during the DNA synthesis/S phase and disappears as cells progress into mitosis, between prophase and metaphase (at protein level). {ECO:0000269\|PubMed:1312467}.
Ptm:		Polyubiquitinated via 'Lys-11'-linked ubiquitin by the anaphase- promoting complex (APC/C), leading to its degradation by the proteasome. Deubiquitinated and stabilized by USP37 enables entry into S phase. {ECO:0000269\|PubMed:21596315}.
Similarity:		Belongs to the cyclin family. Cyclin AB subfamily. {ECO:0000305}.