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UniProt functional annotation for O93427 | ||
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| UniProt code: O93427. |
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| Organism: | |
Crotalus durissus terrificus (South American rattlesnake). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Viperidae; Crotalinae; Crotalus. |
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| Function: | |
Snake venom lectin that activates platelets by binding to the platelet collagen receptor glycoprotein VI (GP6) (PubMed:9153205). The indirect activation of integrin alpha-IIb/beta-3 (ITGA2B/ITGB3) also induced by the toxin is upstream the cytoskeletal translocation of GPIb, FcRgamma (FCER1G) and 14-3-3zeta (YWHAZ)(PubMed:16102113). {ECO:0000269|PubMed:16102113, ECO:0000269|PubMed:9153205}. |
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| Subunit: | |
Tetramer of heterodimers of alpha and beta subunits (alphabeta)(4); disulfide-linked. |
| Subcellular location: | |
Secreted. |
| Tissue specificity: | |
Expressed by the venom gland. |
| Miscellaneous: | |
Does not act by binding to GPIb. {ECO:0000305|PubMed:9153205}. |
| Similarity: | |
Belongs to the snaclec family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.