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UniProt functional annotation for Q5SLR4 | ||
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| UniProt code: Q5SLR4. |
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| Organism: | |
Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8). |
| Taxonomy: | |
Bacteria; Deinococcus-Thermus; Deinococci; Thermales; Thermaceae; Thermus. |
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| Function: | |
The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3) (By similarity). {ECO:0000250|UniProtKB:P37940}. |
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| Catalytic activity: | |
Reaction=3-methyl-2-oxobutanoate + [dihydrolipoyllysine-residue (2- methylpropanoyl)transferase]-(R)-N(6)-lipoyl-L-lysine + H(+) = [dihydrolipoyllysine-residue (2-methylpropanoyl)transferase]-(R)- N(6)-(S(8)-2-methylpropanoyldihydrolipoyl)-L-lysine + CO2; Xref=Rhea:RHEA:13457, Rhea:RHEA-COMP:10488, Rhea:RHEA-COMP:10489, ChEBI:CHEBI:11851, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526, ChEBI:CHEBI:83099, ChEBI:CHEBI:83142; EC=1.2.4.4; Evidence={ECO:0000269|PubMed:15033367}; |
| Cofactor: | |
Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937; Evidence={ECO:0000269|PubMed:15033367}; |
| Subunit: | |
Heterotetramer of two alpha and two beta chains. Directly associated with ODBB in the E1 complex. {ECO:0000269|PubMed:15033367}. |
| Similarity: | |
Belongs to the BCKDHA family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.