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UniProt functional annotation for P12758 | ||
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| UniProt code: P12758. |
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| Organism: | |
Escherichia coli (strain K12). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia. |
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| Function: | |
Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. |
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| Catalytic activity: | |
Reaction=phosphate + uridine = alpha-D-ribose 1-phosphate + uracil; Xref=Rhea:RHEA:24388, ChEBI:CHEBI:16704, ChEBI:CHEBI:17568, ChEBI:CHEBI:43474, ChEBI:CHEBI:57720; EC=2.4.2.3; |
| Pathway: | |
Pyrimidine metabolism; UMP biosynthesis via salvage pathway; uracil from uridine (phosphorylase route): step 1/1. |
| Subunit: | |
Homohexamer. The homohexamer shows 4-fold, 6-fold or 8-fold symmetry. |
| Subcellular location: | |
Cytoplasm. |
| Similarity: | |
Belongs to the PNP/UDP phosphorylase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.