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UniProt functional annotation for P01386 | ||
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| UniProt code: P01386. |
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| Organism: | |
Ophiophagus hannah (King cobra) (Naja hannah). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Colubroidea; Elapidae; Elapinae; Ophiophagus. |
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| Function: | |
Binds with high affinity to muscular (alpha-1/CHRNA1) and neuronal (alpha-7/CHRNA7) nicotinic acetylcholine receptor (nAChR) and inhibits acetylcholine from binding to the receptor, thereby impairing neuromuscular and neuronal transmission. {ECO:0000250|UniProtKB:P60615}. |
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| Subcellular location: | |
Secreted {ECO:0000269|PubMed:4198767}. |
| Tissue specificity: | |
Expressed by the venom gland. {ECO:0000305}. |
| Toxic dose: | |
LD(50) is 0.35 mg/kg by subcutaneous injection. {ECO:0000269|PubMed:4198767}. |
| Similarity: | |
Belongs to the snake three-finger toxin family. Long-chain subfamily. Type II alpha-neurotoxin sub-subfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.