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UniProt functional annotation for P01522 | ||
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| UniProt code: P01522. |
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| Organism: | |
Conus geographus (Geography cone) (Nubecula geographus). |
| Taxonomy: | |
Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda; Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Gastridium. |
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| Function: | |
[Omega-conotoxin GVIA]: Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels (Cav). This toxin blocks N-type calcium channels (Cav2.2/CACNA1B) with a high potency (it displaces [125I]GVIA with an IC(50)=3.7-38 pM) (PubMed:10938268, PubMed:11724570). {ECO:0000269|PubMed:10938268, ECO:0000269|PubMed:11724570}. |
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| Subcellular location: | |
Secreted {ECO:0000269|PubMed:6509012}. |
| Tissue specificity: | |
Expressed by the venom duct. {ECO:0000305|PubMed:6509012}. |
| Domain: | |
The presence of a 'disulfide through disulfide knot' structurally defines this protein as a knottin. {ECO:0000269|PubMed:10231724, ECO:0000269|PubMed:8230223, ECO:0000269|PubMed:8251934, ECO:0000269|PubMed:8338837, ECO:0000269|PubMed:8343203}. |
| Domain: | |
The cysteine framework is VI/VII (C-C-CC-C-C). {ECO:0000305}. |
| Miscellaneous: | |
Has a very low activity on Cav2.1 (it displaces [125I]MVIIC with an IC(50)=1.05 uM) (PubMed:10938268). {ECO:0000269|PubMed:10938268}. |
| Similarity: | |
Belongs to the conotoxin O1 superfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.