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PDBsum entry 1tm0
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Contents |
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* Residue conservation analysis
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References listed in PDB file
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Key reference
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Title
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Functional insights from structural genomics.
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Authors
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F.Forouhar,
A.Kuzin,
J.Seetharaman,
I.Lee,
W.Zhou,
M.Abashidze,
Y.Chen,
W.Yong,
H.Janjua,
Y.Fang,
D.Wang,
K.Cunningham,
R.Xiao,
T.B.Acton,
E.Pichersky,
D.F.Klessig,
C.W.Porter,
G.T.Montelione,
L.Tong.
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Ref.
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J Struct Funct Genomics, 2007,
8,
37-44.
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PubMed id
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Abstract
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Structural genomics efforts have produced structural information, either
directly or by modeling, for thousands of proteins over the past few years.
While many of these proteins have known functions, a large percentage of them
have not been characterized at the functional level. The structural information
has provided valuable functional insights on some of these proteins, through
careful structural analyses, serendipity, and structure-guided functional
screening. Some of the success stories based on structures solved at the
Northeast Structural Genomics Consortium (NESG) are reported here. These include
a novel methyl salicylate esterase with important role in plant innate immunity,
a novel RNA methyltransferase (H. influenzae yggJ (HI0303)), a novel
spermidine/spermine N-acetyltransferase (B. subtilis PaiA), a novel
methyltransferase or AdoMet binding protein (A. fulgidus AF_0241), an
ATP:cob(I)alamin adenosyltransferase (B. subtilis YvqK), a novel carboxysome
pore (E. coli EutN), a proline racemase homolog with a disrupted active site (B.
melitensis BME11586), an FMN-dependent enzyme (S. pneumoniae SP_1951), and a
12-stranded beta-barrel with a novel fold (V. parahaemolyticus VPA1032).
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