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UniProt functional annotation for P01523 | ||
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| UniProt code: P01523. |
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| Organism: | |
Conus geographus (Geography cone) (Nubecula geographus). |
| Taxonomy: | |
Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda; Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Gastridium. |
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| Function: | |
Mu-conotoxins block voltage-gated sodium channels (Nav). This toxin potently blocks rat Nav1.4/SCN4A (IC(50)= 19-110 nM) (PubMed:1654319, PubMed:1326324, PubMed:10627583, PubMed:21652775, PubMed:30360356). It also moderately blocks rNav1.1/SCN1A (Kd=260 nM), rNav1.2/SCN2A (IC(50)=2.7-17.8 uM), and mNav1.6/SCN8A (IC(50)=680 nM) (PubMed:10627583, PubMed:21652775). The inhibition is reversible. In vivo, induces paralysis to an isolated skeletal muscle preparation from frog (cutaneous pectoralis) within a few minutes (PubMed:2410412). {ECO:0000269|PubMed:10627583, ECO:0000269|PubMed:18950653, ECO:0000269|PubMed:21652775, ECO:0000269|PubMed:2410412, ECO:0000269|PubMed:30360356}. |
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| Subcellular location: | |
Secreted {ECO:0000269|PubMed:6852238}. |
| Tissue specificity: | |
Expressed by the venom duct. {ECO:0000305|PubMed:6852238}. |
| Domain: | |
The cysteine framework is III (CC-C-C-CC). Classified in the M- 4 branch, since 4 residues stand between the fourth and the fifth cysteine residues. {ECO:0000305}. |
| Ptm: | |
Hydroxylated; hydroxylations improve the ability to block Nav1.4/SCN4A sodium channels but does not affect folding. {ECO:0000269|PubMed:1991506, ECO:0000269|PubMed:2069951}. |
| Miscellaneous: | |
This toxin does not or only weakly blocks rNav1.3/SCN3A, rNav1.5/SCN5A, rNav1.7/SCN9A (IC(50)=6.0 uM and >100 uM), and rNav1.8/SCN10A (PubMed:10627583, PubMed:21652775). {ECO:0000269|PubMed:10627583, ECO:0000269|PubMed:21652775}. |
| Similarity: | |
Belongs to the conotoxin M superfamily. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.