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UniProt functional annotation for P0A0L2 | ||
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| UniProt code: P0A0L2. |
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| Organism: | |
Staphylococcus aureus. |
| Taxonomy: | |
Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae; Staphylococcus. |
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| Function: | |
Staphylococcal enterotoxin that activates the host immune system by binding as unprocessed molecules to major histocompatibility (MHC) complex class II and T-cell receptor (TCR) molecules (PubMed:2658055, PubMed:12467569). In turn, waves of cellular activation, cytokine production, and migration into the lung tissue and airways occur via alphabeta T-cells (PubMed:23321986). Causes also the intoxication staphylococcal food poisoning syndrome. The illness is characterized by high fever, hypotension, diarrhea, shock, and in some cases death (Probable). {ECO:0000269|PubMed:12467569, ECO:0000269|PubMed:23321986, ECO:0000269|PubMed:2658055, ECO:0000305|PubMed:22069659}. |
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| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit. The zinc ion is necessary for the toxin interaction with MHC class II.; |
| Subunit: | |
Monomer. Interacts with MHC class II molecules alpha/HLA-DRB1 and beta/HLA-DRA chains (PubMed:2658055, PubMed:12467569, PubMed:11847286). The interaction with MHC-II molecules occurs at both zinc-dependent and zinc-independent sites (PubMed:2658055, PubMed:12467569). Interacts with T-cell receptor beta variable 7- 9/TRBV7-9 (PubMed:27180909). {ECO:0000269|PubMed:11847286, ECO:0000269|PubMed:12467569, ECO:0000269|PubMed:2658055, ECO:0000269|PubMed:27180909}. |
| Subcellular location: | |
Secreted. |
| Miscellaneous: | |
This toxin seems to be coded by a bacteriophage. |
| Similarity: | |
Belongs to the staphylococcal/streptococcal toxin family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.