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PDBsum entry 1svb
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Viral protein
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PDB id
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1svb
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References listed in PDB file
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Key reference
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Title
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The envelope glycoprotein from tick-Borne encephalitis virus at 2 a resolution.
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Authors
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F.A.Rey,
F.X.Heinz,
C.Mandl,
C.Kunz,
S.C.Harrison.
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Ref.
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Nature, 1995,
375,
291-298.
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PubMed id
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Abstract
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The crystallographically determined structure of a soluble fragment from the
major envelope protein of a flavivirus reveals an unusual architecture. The
flat, elongated dimer extends in a direction that would be parallel to the viral
membrane. Residues that influence binding of monoclonal antibodies lie on the
outward-facing surface of the protein. The clustering of mutations that affect
virulence in various flaviviruses indicates a possible receptor binding site
and, together with other mutational and biochemical data, suggests a picture for
the fusion-activating, conformational change triggered by low pH.
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