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UniProt functional annotation for P07268 | ||
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| UniProt code: P07268. |
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| Organism: | |
Serratia marcescens (strain ATCC 21074 / E-15). |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Yersiniaceae; Serratia; unclassified Serratia. |
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| Function: | |
Naturally present in the silkworm intestine and allows the emerging moth to dissolve its cocoon. |
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| Catalytic activity: | |
Reaction=Preferential cleavage of bonds with hydrophobic residues in P1'.; EC=3.4.24.40; |
| Cofactor: | |
Name=Ca(2+); Xref=ChEBI:CHEBI:29108; Note=Binds 7 Ca(2+) ions per subunit.; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.; |
| Subcellular location: | |
Secreted. |
| Miscellaneous: | |
The Gly-rich repeats may be important in the extracellular secretion of this metalloprotease. |
| Miscellaneous: | |
In Japan this enzyme, isolated from a Serratia strain presents in the gut of silkworms, is used as a food supplement because it is reported to induces fibrinolytic, anti-inflammatory and anti- edemic (prevents swelling and fluid retention) activity in a number of tissues. |
| Similarity: | |
Belongs to the peptidase M10B family. {ECO:0000305}. |
| Sequence caution: | |
Sequence=CAA27738.1; Type=Frameshift; Evidence={ECO:0000305}; |
Annotations taken from UniProtKB at the EBI.