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UniProt functional annotation for Q9SF23 | ||
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| UniProt code: Q9SF23. |
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| Organism: | |
Arabidopsis thaliana (Mouse-ear cress). |
| Taxonomy: | |
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis. |
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| Function: | |
Catalyzes the conversion of 7,8-dihydroneopterin into 6- hydroxymethyl-7,8-dihydropterin, a biosynthetic precursor of the vitamin tetrahydrofolate. Can use L-threo-dihydroneopterin and D- erythro-dihydroneopterin as substrates for the formation of 6- hydroxymethyldihydropterin, but it can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin. {ECO:0000269|PubMed:15107504, ECO:0000269|PubMed:15165863}. |
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| Catalytic activity: | |
Reaction=7,8-dihydroneopterin = 6-hydroxymethyl-7,8-dihydropterin + glycolaldehyde; Xref=Rhea:RHEA:10540, ChEBI:CHEBI:17001, ChEBI:CHEBI:17071, ChEBI:CHEBI:44841; EC=4.1.2.25; Evidence={ECO:0000269|PubMed:15107504, ECO:0000269|PubMed:15165863}; |
| Pathway: | |
Cofactor biosynthesis; tetrahydrofolate biosynthesis; 2-amino- 4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 7,8- dihydroneopterin triphosphate: step 3/4. {ECO:0000305}. |
| Subunit: | |
Homooctamer. Forms a hollow cylinder assembled from two ring- shaped tetramers. {ECO:0000269|PubMed:15165863}. |
| Tissue specificity: | |
Expressed in roots, leaves, stems and siliques. {ECO:0000269|PubMed:15107504}. |
| Similarity: | |
Belongs to the DHNA family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.