UniProt functional annotation for P27838



	UniProt functional annotation for P27838

UniProt code: P27838.

Organism: Escherichia coli (strain K12).

Taxonomy: Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.

Function: Involved in iron-sulfur (Fe-S) cluster assembly (PubMed:16603772, PubMed:19305405, PubMed:21799759, PubMed:25430730). May act as a regulator of Fe-S biogenesis (PubMed:19305405, PubMed:21799759, PubMed:25430730). Can bind both Fe(2+) and Fe(3+) ions (PubMed:15530368, PubMed:16603772, PubMed:17244611, PubMed:17651435). In vivo, has a positive effect on Fe-S cluster biogenesis under iron- rich growth conditions (PubMed:25430730). In vitro, can inhibit IscS cysteine desulfurase activity and the formation of Fe-S clusters on IscU (PubMed:19305405, PubMed:21799759). In vitro, in the presence of IscS and cysteine, Fe(3+)-CyaY can be used as an iron donor during Fe-S cluster assembly on the scaffold protein IscU (PubMed:16603772). {ECO:0000269|PubMed:15530368, ECO:0000269|PubMed:16603772, ECO:0000269|PubMed:17244611, ECO:0000269|PubMed:17651435, ECO:0000269|PubMed:19305405, ECO:0000269|PubMed:21799759, ECO:0000269|PubMed:25430730}.

Activity regulation: Binds iron under oxidative stress conditions, but not under conditions emulating the intracellular redox potential. {ECO:0000269|PubMed:17244611}.

Subunit: Monomer (PubMed:16603772, PubMed:19305405, PubMed:28931050). Forms homodimers and higher oligomers in the presence of iron (PubMed:16603772, PubMed:28931050). Interacts with IscS (PubMed:16603772, PubMed:19305405, PubMed:25430730). {ECO:0000269|PubMed:16603772, ECO:0000269|PubMed:19305405, ECO:0000269|PubMed:25430730, ECO:0000269|PubMed:28931050}.

Disruption phenotype: Cells are not affected in cellular iron content and sensitivity to oxidants. {ECO:0000269|PubMed:10452520}.

Similarity: Belongs to the frataxin family. {ECO:0000255|HAMAP- Rule:MF_00142, ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Escherichia coli (strain K12).
Taxonomy:		Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia.



Function:		Involved in iron-sulfur (Fe-S) cluster assembly (PubMed:16603772, PubMed:19305405, PubMed:21799759, PubMed:25430730). May act as a regulator of Fe-S biogenesis (PubMed:19305405, PubMed:21799759, PubMed:25430730). Can bind both Fe(2+) and Fe(3+) ions (PubMed:15530368, PubMed:16603772, PubMed:17244611, PubMed:17651435). In vivo, has a positive effect on Fe-S cluster biogenesis under iron- rich growth conditions (PubMed:25430730). In vitro, can inhibit IscS cysteine desulfurase activity and the formation of Fe-S clusters on IscU (PubMed:19305405, PubMed:21799759). In vitro, in the presence of IscS and cysteine, Fe(3+)-CyaY can be used as an iron donor during Fe-S cluster assembly on the scaffold protein IscU (PubMed:16603772). {ECO:0000269\|PubMed:15530368, ECO:0000269\|PubMed:16603772, ECO:0000269\|PubMed:17244611, ECO:0000269\|PubMed:17651435, ECO:0000269\|PubMed:19305405, ECO:0000269\|PubMed:21799759, ECO:0000269\|PubMed:25430730}.


Activity regulation:		Binds iron under oxidative stress conditions, but not under conditions emulating the intracellular redox potential. {ECO:0000269\|PubMed:17244611}.
Subunit:		Monomer (PubMed:16603772, PubMed:19305405, PubMed:28931050). Forms homodimers and higher oligomers in the presence of iron (PubMed:16603772, PubMed:28931050). Interacts with IscS (PubMed:16603772, PubMed:19305405, PubMed:25430730). {ECO:0000269\|PubMed:16603772, ECO:0000269\|PubMed:19305405, ECO:0000269\|PubMed:25430730, ECO:0000269\|PubMed:28931050}.
Disruption phenotype:		Cells are not affected in cellular iron content and sensitivity to oxidants. {ECO:0000269\|PubMed:10452520}.
Similarity:		Belongs to the frataxin family. {ECO:0000255\|HAMAP- Rule:MF_00142, ECO:0000305}.