UniProt functional annotation for Q8R426



	UniProt functional annotation for Q8R426

UniProt code: Q8R426.

Organism: Rattus norvegicus (Rat).

Taxonomy: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.

Function: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels (PubMed:14980206). Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:14980206). Modulates KCND2/Kv4.2 currents (PubMed:14980206). In vitro, modulates KCND1/Kv4.1 currents (By similarity). Increases the presence of KCND2 at the cell surface (PubMed:14980206). {ECO:0000250|UniProtKB:Q9NZI2, ECO:0000269|PubMed:12646414, ECO:0000269|PubMed:14980206}.

Subunit: Component of heteromultimeric potassium channels (PubMed:15356203, PubMed:14980206). Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity). Part of a heterooctamer composed of the tetrameric channel and four KCNIP1 chains (By similarity). Interacts with KCND3 and the N-terminal domain of KCND2. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2 (PubMed:14980206). Self-associates to form homodimers and homotetramers. Interacts with KCNIP2 isoform 3 in a calcium-dependent manner. {ECO:0000250|UniProtKB:Q9JJ57, ECO:0000250|UniProtKB:Q9NZI2, ECO:0000269|PubMed:10676964, ECO:0000269|PubMed:11423117, ECO:0000269|PubMed:14980206, ECO:0000269|PubMed:15356203}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:14980206, ECO:0000269|PubMed:15356203}; Peripheral membrane protein {ECO:0000269|PubMed:14980206}. Cytoplasm {ECO:0000269|PubMed:14980206, ECO:0000269|PubMed:15356203}. Cell projection, dendrite {ECO:0000269|PubMed:15356203}.

Tissue specificity: Detected in hippocampus and in the molecular layer of the dentate gyrus (at protein level) (PubMed:15356203). Isoform 1 and isoform 2 are predominantly expressed at equal levels in brain. Colocalizes with KCND3 in inhibitory interneurons in cortex and hippocampus and in striatal interneurons. {ECO:0000269|PubMed:10676964, ECO:0000269|PubMed:12646414, ECO:0000269|PubMed:15356203}.

Similarity: Belongs to the recoverin family. {ECO:0000305}.

Annotations taken from UniProtKB at the EBI.


Organism:		Rattus norvegicus (Rat).
Taxonomy:		Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus.



Function:		Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels (PubMed:14980206). Regulates channel density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner (PubMed:14980206). Modulates KCND2/Kv4.2 currents (PubMed:14980206). In vitro, modulates KCND1/Kv4.1 currents (By similarity). Increases the presence of KCND2 at the cell surface (PubMed:14980206). {ECO:0000250\|UniProtKB:Q9NZI2, ECO:0000269\|PubMed:12646414, ECO:0000269\|PubMed:14980206}.


Subunit:		Component of heteromultimeric potassium channels (PubMed:15356203, PubMed:14980206). Identified in potassium channel complexes containing KCND1, KCND2, KCND3, KCNIP1, KCNIP2, KCNIP3, KCNIP4, DPP6 and DPP10 (By similarity). Part of a heterooctamer composed of the tetrameric channel and four KCNIP1 chains (By similarity). Interacts with KCND3 and the N-terminal domain of KCND2. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2 (PubMed:14980206). Self-associates to form homodimers and homotetramers. Interacts with KCNIP2 isoform 3 in a calcium-dependent manner. {ECO:0000250\|UniProtKB:Q9JJ57, ECO:0000250\|UniProtKB:Q9NZI2, ECO:0000269\|PubMed:10676964, ECO:0000269\|PubMed:11423117, ECO:0000269\|PubMed:14980206, ECO:0000269\|PubMed:15356203}.
Subcellular location:		Cell membrane {ECO:0000269\|PubMed:14980206, ECO:0000269\|PubMed:15356203}; Peripheral membrane protein {ECO:0000269\|PubMed:14980206}. Cytoplasm {ECO:0000269\|PubMed:14980206, ECO:0000269\|PubMed:15356203}. Cell projection, dendrite {ECO:0000269\|PubMed:15356203}.
Tissue specificity:		Detected in hippocampus and in the molecular layer of the dentate gyrus (at protein level) (PubMed:15356203). Isoform 1 and isoform 2 are predominantly expressed at equal levels in brain. Colocalizes with KCND3 in inhibitory interneurons in cortex and hippocampus and in striatal interneurons. {ECO:0000269\|PubMed:10676964, ECO:0000269\|PubMed:12646414, ECO:0000269\|PubMed:15356203}.
Similarity:		Belongs to the recoverin family. {ECO:0000305}.