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UniProt functional annotation for Q9R381 | ||
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| UniProt code: Q9R381. |
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| Organism: | |
Salmonella enteritidis. |
| Taxonomy: | |
Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Salmonella. |
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| Function: | |
Catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring including amikacin, tobramycin, dibekacin and ribostamycin. Able to acetylate eukaryotic histone proteins. {ECO:0000269|PubMed:10542165, ECO:0000269|PubMed:15123251}. |
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| Catalytic activity: | |
Reaction=acetyl-CoA + kanamycin B = CoA + H(+) + N(6')-acetylkanamycin B; Xref=Rhea:RHEA:16449, ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57288, ChEBI:CHEBI:58390, ChEBI:CHEBI:58549; EC=2.3.1.82; Evidence={ECO:0000269|PubMed:10542165, ECO:0000269|PubMed:15123251, ECO:0000269|PubMed:18095712}; |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:15123251, ECO:0000269|PubMed:18095712}. |
Annotations taken from UniProtKB at the EBI.