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UniProt functional annotation for P83917 | ||
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| UniProt codes: P83917, P23197. |
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| Organism: | |
Mus musculus (Mouse). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus. |
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| Function: | |
Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane. {ECO:0000269|PubMed:11242053, ECO:0000269|PubMed:11571267}. |
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| Subunit: | |
Homodimer (PubMed:10747027). Interacts directly with CHAF1A, EMSY, LBR, TIF1/TIF1A and TRIM28/TIF1B PXVXL motif via the chromoshadow domain (PubMed:8978696, PubMed:10562550, PubMed:10747027). Interacts directly with histone H3 methylated at 'Lys-9' via the chromo domain (PubMed:11571267). Interacts with SUV39H1, SETDB1, KMT5B and KMT5C (PubMed:10202156, PubMed:15145825). Interacts with PRDM6 (PubMed:16537907). Interacts with POGZ (By similarity). Interacts with CHAMP1 (By similarity). Interacts with INCENP (By similarity). Interacts with SGO1; the CBX1 homodimer binds to one molecule of SGO1 (By similarity). Interacts with LRIF1 (via PxVxL motif) (By similarity). {ECO:0000250|UniProtKB:P83916, ECO:0000269|PubMed:10202156, ECO:0000269|PubMed:10562550, ECO:0000269|PubMed:10747027, ECO:0000269|PubMed:11571267, ECO:0000269|PubMed:15145825, ECO:0000269|PubMed:16537907, ECO:0000269|PubMed:8978696}. |
| Subcellular location: | |
Nucleus {ECO:0000250}. Note=Unassociated with chromosomes during mitosis. {ECO:0000250}. |
| Tissue specificity: | |
In all adult and embryonic tissues. {ECO:0000269|PubMed:1708124}. |
| Ptm: | |
Not phosphorylated. {ECO:0000250}. |
| Ptm: | |
Ubiquitinated. |
Annotations taken from UniProtKB at the EBI.