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PDBsum entry 1s1s
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References listed in PDB file
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Key reference
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Title
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Design and synthesis of indolo[2,3-A]quinolizin-7-One inhibitors of the zipa-Ftsz interaction.
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Authors
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L.D.Jennings,
K.W.Foreman,
T.S.Rush,
D.H.Tsao,
L.Mosyak,
Y.Li,
M.N.Sukhdeo,
W.Ding,
E.G.Dushin,
C.H.Kenny,
S.L.Moghazeh,
P.J.Petersen,
A.V.Ruzin,
M.Tuckman,
A.G.Sutherland.
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Ref.
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Bioorg Med Chem Lett, 2004,
14,
1427-1431.
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PubMed id
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Abstract
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The binding of FtsZ to ZipA is a potential target for antibacterial therapy.
Based on a small molecule inhibitor of the ZipA-FtsZ interaction, a parallel
synthesis of small molecules was initiated which targeted a key region of ZipA
involved in FtsZ binding. The X-ray crystal structure of one of these molecules
complexed with ZipA was solved. The structure revealed an unexpected binding
mode, facilitated by desolvation of a loosely bound surface water.
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