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UniProt functional annotation for P82197 | ||
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| UniProt code: P82197. |
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| Organism: | |
Ovis aries (Sheep). |
| Taxonomy: | |
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis. |
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| Function: | |
Catalyzes the phosphorylation of the dietary vitamin B6 vitamers pyridoxal (PL), pyridoxine (PN) and pyridoxamine (PM) to form pyridoxal 5'-phosphate (PLP), pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), respectively (PubMed:14722069) (By similarity). PLP is the active form of vitamin B6, and acts as a cofactor for over 140 different enzymatic reactions (By similarity). {ECO:0000250|UniProtKB:O00764, ECO:0000305|PubMed:14722069}. |
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| Catalytic activity: | |
Reaction=ATP + pyridoxal = ADP + H(+) + pyridoxal 5'-phosphate; Xref=Rhea:RHEA:10224, ChEBI:CHEBI:15378, ChEBI:CHEBI:17310, ChEBI:CHEBI:30616, ChEBI:CHEBI:456216, ChEBI:CHEBI:597326; EC=2.7.1.35; Evidence={ECO:0000250|UniProtKB:O00764}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:10225; Evidence={ECO:0000250|UniProtKB:O00764}; |
| Catalytic activity: | |
Reaction=ATP + pyridoxamine = ADP + H(+) + pyridoxamine 5'-phosphate; Xref=Rhea:RHEA:25104, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:57761, ChEBI:CHEBI:58451, ChEBI:CHEBI:456216; EC=2.7.1.35; Evidence={ECO:0000250|UniProtKB:O00764}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25105; Evidence={ECO:0000250|UniProtKB:O00764}; |
| Catalytic activity: | |
Reaction=ATP + pyridoxine = ADP + H(+) + pyridoxine 5'-phosphate; Xref=Rhea:RHEA:25108, ChEBI:CHEBI:15378, ChEBI:CHEBI:16709, ChEBI:CHEBI:30616, ChEBI:CHEBI:58589, ChEBI:CHEBI:456216; EC=2.7.1.35; Evidence={ECO:0000250|UniProtKB:O00764}; PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:25109; Evidence={ECO:0000250|UniProtKB:O00764}; |
| Cofactor: | |
Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Evidence={ECO:0000305|PubMed:12235162, ECO:0000305|PubMed:14722069}; Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250|UniProtKB:O00764}; |
| Activity regulation: | |
Activated by K(+) (Probable). Activity is increased in the presence of Na(+) (By similarity). {ECO:0000250|UniProtKB:O00764, ECO:0000305|PubMed:12235162, ECO:0000305|PubMed:14722069}. |
| Pathway: | |
Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxal 5'-phosphate from pyridoxal: step 1/1. {ECO:0000250|UniProtKB:O00764}. |
| Pathway: | |
Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxine 5'-phosphate from pyridoxine: step 1/1. {ECO:0000250|UniProtKB:O00764}. |
| Pathway: | |
Cofactor metabolism; pyridoxal 5'-phosphate salvage; pyridoxamine 5'-phosphate from pyridoxamine: step 1/1. {ECO:0000250|UniProtKB:O00764}. |
| Subunit: | |
Homodimer. {ECO:0000269|PubMed:12198308, ECO:0000269|PubMed:12235162, ECO:0000269|PubMed:14722069}. |
| Subcellular location: | |
Cytoplasm, cytosol {ECO:0000250|UniProtKB:O00764}. |
| Tissue specificity: | |
Ubiquitous. |
| Similarity: | |
Belongs to the pyridoxine kinase family. {ECO:0000305}. |
Annotations taken from UniProtKB at the EBI.